Time course of hyperalgesia in the rat chronic constriction injury model of neuropathic pain
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چکیده
منابع مشابه
Microinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model
Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and ho...
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Despite extensive investigations, the main mechanisms underlying neuropathic pain development are still not fully understood and there is no effective treatment for that. So intensive research is being done for finding new, efficient analgesic drugs. 56 male Wistar rats (230±30) were divided into 7 groups (n=8); control, sham, CCI and 3 Umbelliprenin groups (25, 50 and 100 microgram/rat)...
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Introduction: Neuropathic pain is a chronic pain that results from damage to the central and peripheral nerves. According to the previous studies, curcumin and exercise can be effective treatments for alleviating sensory neuropathic pain individually. Now the combined effect of chronic curcumin (Cur) and forced exercise on behavioral pain responses in the neuropathic pain model of chronic const...
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Background: Neuropathic pain is a chronic pain caused by damage to the central nervous system and the peripheral. Caffeine is a non-selective antagonist of A1, A2a, receptors of adenosine, which has a protective effect on neuropathic pain in some doses by inhibiting A2a, A2b receptors. Considering that the nitric oxide (NO) levels are apparently effective in the parts of caffeine central effect...
متن کاملEffects of combined chronic progesterone administration and forced exercise on behavioral pain responses in the neuropathic pain model of chronic constriction injury in rats
Introduction: Neuropathic pain is a chronic pain that results from damage to the central and peripheral nerves. According to the previous studies, physical activity or progesterone can be an effective treatment for alleviating sensory neuropathic pain individually. In this way, the combined effect of chronic progesterone and forced exercise on behavioral pain responses in the neuropathic pain m...
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ژورنال
عنوان ژورنال: HAMDAN MEDICAL JOURNAL
سال: 2015
ISSN: 2227-247X,2227-2437
DOI: 10.7707/hmj.521